Nature Communications (Dec 2020)
Eosinophils improve cardiac function after myocardial infarction
- Jing Liu,
- Chongzhe Yang,
- Tianxiao Liu,
- Zhiyong Deng,
- Wenqian Fang,
- Xian Zhang,
- Jie Li,
- Qin Huang,
- Conglin Liu,
- Yunzhe Wang,
- Dafeng Yang,
- Galina K. Sukhova,
- Jes S. Lindholt,
- Axel Diederichsen,
- Lars M. Rasmussen,
- Dazhu Li,
- Gail Newton,
- Francis W. Luscinskas,
- Lijun Liu,
- Peter Libby,
- Jing Wang,
- Junli Guo,
- Guo-Ping Shi
Affiliations
- Jing Liu
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Chongzhe Yang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Tianxiao Liu
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Zhiyong Deng
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Wenqian Fang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Xian Zhang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Jie Li
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Qin Huang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Conglin Liu
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yunzhe Wang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Dafeng Yang
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Galina K. Sukhova
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Jes S. Lindholt
- Department of Cardiothoracic and Vascular Surgery, Odense University Hospital
- Axel Diederichsen
- Elitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital
- Lars M. Rasmussen
- Elitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital
- Dazhu Li
- Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Gail Newton
- Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
- Francis W. Luscinskas
- Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
- Lijun Liu
- Department of Biochemistry and Cancer Biology, College of Medicine and Life Sciences, University of Toledo
- Peter Libby
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Jing Wang
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College
- Junli Guo
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Guo-Ping Shi
- Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-19297-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Blood eosinophil (EOS) counts may serve as risk factors for human coronary heart diseases. Here the authors show that increased circulating and myocardial EOS after myocardial infarction play a cardioprotective role by reducing cardiomyocyte death, cardiac fibroblast activation and fibrosis, and endothelium activation-mediated inflammatory cell accumulation.
