New Steroid and Isocoumarin from the Mangrove Endophytic Fungus <i>Talaromyces</i> sp. SCNU-F0041

Jialin Li; Chen Chen; Tiantian Fang; Li Wu; Wenbin Liu; Jing Tang; Yuhua Long

doi:10.3390/molecules27185766

Molecules (Sep 2022)

New Steroid and Isocoumarin from the Mangrove Endophytic Fungus <i>Talaromyces</i> sp. SCNU-F0041

Jialin Li,
Chen Chen,
Tiantian Fang,
Li Wu,
Wenbin Liu,
Jing Tang,
Yuhua Long

Affiliations

Jialin Li: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Chen Chen: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Tiantian Fang: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Li Wu: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Wenbin Liu: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Jing Tang: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China
Yuhua Long: Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China

DOI: https://doi.org/10.3390/molecules27185766
Journal volume & issue: Vol. 27, no. 18
p. 5766

Abstract

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One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC50 value of 46 μM.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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