Communications Biology (Jan 2023)
An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling
- Nuzulul Kurniansyah,
- Danielle A. Wallace,
- Ying Zhang,
- Bing Yu,
- Brian Cade,
- Heming Wang,
- Heather M. Ochs-Balcom,
- Alexander P. Reiner,
- Alberto R. Ramos,
- Joshua D. Smith,
- Jianwen Cai,
- Martha Daviglus,
- Phyllis C. Zee,
- Robert Kaplan,
- Charles Kooperberg,
- Stephen S. Rich,
- Jerome I. Rotter,
- Sina A. Gharib,
- Susan Redline,
- Tamar Sofer
Affiliations
- Nuzulul Kurniansyah
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Danielle A. Wallace
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Ying Zhang
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Bing Yu
- Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Brian Cade
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Heming Wang
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Heather M. Ochs-Balcom
- Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York
- Alexander P. Reiner
- Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York
- Alberto R. Ramos
- Department of Neurology, University of Miami Miller School of Medicine
- Joshua D. Smith
- Northwest Genomic Center, University of Washington
- Jianwen Cai
- Department of Biostatistics, University of North Carolina
- Martha Daviglus
- Institute for Minority Health Research, University of Illinois at Chicago
- Phyllis C. Zee
- Division of Sleep Medicine, Department of Neurology, Northwestern University
- Robert Kaplan
- Division of Public Health Sciences, Fred Hutchinson Cancer Center
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Center
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia School of Medicine
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Sina A. Gharib
- Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington
- Susan Redline
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Tamar Sofer
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/s42003-023-04520-y
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 11
Abstract
An integrated multi-omics analysis identifies an association chain among sleep-disordered breathing (SDB) traits, gene expression in circulating leukocytes, and serum metabolites, and supports a mechanistic role for P2XR4 purinergic signaling in SDB.
