Nature Communications (Apr 2020)
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
- Joana A. Revez,
- Tian Lin,
- Zhen Qiao,
- Angli Xue,
- Yan Holtz,
- Zhihong Zhu,
- Jian Zeng,
- Huanwei Wang,
- Julia Sidorenko,
- Kathryn E. Kemper,
- Anna A. E. Vinkhuyzen,
- Julanne Frater,
- Darryl Eyles,
- Thomas H. J. Burne,
- Brittany Mitchell,
- Nicholas G. Martin,
- Gu Zhu,
- Peter M. Visscher,
- Jian Yang,
- Naomi R. Wray,
- John J. McGrath
Affiliations
- Joana A. Revez
- Institute for Molecular Bioscience, The University of Queensland
- Tian Lin
- Institute for Molecular Bioscience, The University of Queensland
- Zhen Qiao
- Institute for Molecular Bioscience, The University of Queensland
- Angli Xue
- Institute for Molecular Bioscience, The University of Queensland
- Yan Holtz
- Queensland Brain Institute, The University of Queensland
- Zhihong Zhu
- Institute for Molecular Bioscience, The University of Queensland
- Jian Zeng
- Institute for Molecular Bioscience, The University of Queensland
- Huanwei Wang
- Institute for Molecular Bioscience, The University of Queensland
- Julia Sidorenko
- Institute for Molecular Bioscience, The University of Queensland
- Kathryn E. Kemper
- Institute for Molecular Bioscience, The University of Queensland
- Anna A. E. Vinkhuyzen
- Institute for Molecular Bioscience, The University of Queensland
- Julanne Frater
- Queensland Brain Institute, The University of Queensland
- Darryl Eyles
- Queensland Brain Institute, The University of Queensland
- Thomas H. J. Burne
- Queensland Brain Institute, The University of Queensland
- Brittany Mitchell
- QIMR Berghofer Medical Research Institute
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- Gu Zhu
- QIMR Berghofer Medical Research Institute
- Peter M. Visscher
- Institute for Molecular Bioscience, The University of Queensland
- Jian Yang
- Institute for Molecular Bioscience, The University of Queensland
- Naomi R. Wray
- Institute for Molecular Bioscience, The University of Queensland
- John J. McGrath
- Queensland Brain Institute, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-020-15421-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Vitamin D is a precursor of the steroid hormone 1,25-dihydroxyvitamin D3, and its deficiency is associated with many adverse health outcomes. Here, Revez et al. perform a genome-wide association study for circulating 25-hydroxyvitamin D in 417,580 individuals and test for potential causal relationships with other traits using Mendelian randomization.
