Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Mark Ultsch; Michael J. Holliday; Stefan Gerhardy; Paul Moran; Suzie J. Scales; Nidhi Gupta; Francesca Oltrabella; Cecilia Chiu; Wayne Fairbrother; Charles Eigenbrot; Daniel Kirchhofer

doi:10.1038/s42003-021-02387-5

Communications Biology (Jul 2021)

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Mark Ultsch,
Michael J. Holliday,
Stefan Gerhardy,
Paul Moran,
Suzie J. Scales,
Nidhi Gupta,
Francesca Oltrabella,
Cecilia Chiu,
Wayne Fairbrother,
Charles Eigenbrot,
Daniel Kirchhofer

Affiliations

Mark Ultsch: Department of Structural Biology, Genentech Inc.
Michael J. Holliday: Department of Early Discovery Biochemistry, Genentech Inc.
Stefan Gerhardy: Department of Early Discovery Biochemistry, Genentech Inc.
Paul Moran: Department of Early Discovery Biochemistry, Genentech Inc.
Suzie J. Scales: Department of Immunology, Genentech Inc.
Nidhi Gupta: Department of Immunology, Genentech Inc.
Francesca Oltrabella: Department of Immunology, Genentech Inc.
Cecilia Chiu: Department of Antibody Engineering, Genentech Inc.
Wayne Fairbrother: Department of Early Discovery Biochemistry, Genentech Inc.
Charles Eigenbrot: Department of Structural Biology, Genentech Inc.
Daniel Kirchhofer: Department of Early Discovery Biochemistry, Genentech Inc.

DOI: https://doi.org/10.1038/s42003-021-02387-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

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Mark Ultsch et al. report X-ray and NMR structures of the N-terminal domain of two closely related innate immunity proteins, ApoL1 and ApoL2. Their findings contribute to a better understanding of the ApoL immune protein family.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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