Epigenetic-related gene-based prognostic model construction and validation in prostate adenocarcinoma

Youyou Li; Chao Li; Longxiang Wu; Jiaren Li; Yu Gan; Shuo Tan; Lei Zhou; Wei Xiong; Liang Zhou; Cheng Li; Jiahao Liu; Dingwen Liu; Yichuan Wang; Yunlong Fu; Kun Yao; Long Wang

Heliyon (May 2024)

Epigenetic-related gene-based prognostic model construction and validation in prostate adenocarcinoma

Youyou Li,
Chao Li,
Longxiang Wu,
Jiaren Li,
Yu Gan,
Shuo Tan,
Lei Zhou,
Wei Xiong,
Liang Zhou,
Cheng Li,
Jiahao Liu,
Dingwen Liu,
Yichuan Wang,
Yunlong Fu,
Kun Yao,
Long Wang

Affiliations

Youyou Li: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Chao Li: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Longxiang Wu: Department of Urology, The Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Jiaren Li: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Yu Gan: Department of Urology, The Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Shuo Tan: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Lei Zhou: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Wei Xiong: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Liang Zhou: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Cheng Li: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Jiahao Liu: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Dingwen Liu: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Yichuan Wang: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Yunlong Fu: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Kun Yao: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Long Wang: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China; Corresponding author.

Journal volume & issue: Vol. 10, no. 10
p. e30941

Abstract

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Prostate adenocarcinoma (PRAD), driven by both genetic and epigenetic factors, is a common malignancy that affects men worldwide. We aimed to identify and characterize differentially expressed epigenetic-related genes (ERGs) in PRAD and investigate their potential roles in disease progression and prognosis. We used PRAD samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to identify prognosis-associated ERGs. Thirteen ERGs with two distinct expression profiles were identified through consensus clustering. Gene set variation analysis highlighted differences in pathway activities, particularly in the Hedgehog and Notch pathways. Higher epigenetic scores correlated with favorable prognosis and improved immunotherapeutic response. Experimental validation underscored the importance of CBX3 and KAT2A, suggesting their pivotal roles in PRAD. This study provides crucial insights into the epigenetic scoring approach and presents a promising prognostic tool, with CBX3 and KAT2A as key players. These findings pave the way for targeted and personalized interventions for the treatment of PRAD.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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