Synthesis and antibacterial activity of modified ε-polylysine

Abstract

In this paper, Ugi reaction was used to synthesize the modified polylysine (M-ε-PL) in two steps, and OD value was measured by ultraviolet spectrophotometer to determine the inhibitory rate of M-ε-PL in different concentrations of Escherichia coli and Staphylococcus aureus. The results showed that the antibacterial effect was better with the increase of concentration of M-ε-PL. Among them, 20 mg/mL M-εPL had better bacteriostatic effect on E. coli and S. aureus. The antibacterial rate was 70% and 44%.