Communications Medicine (Mar 2023)
Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults
- Amy C. Thomas,
- Elizabeth Oliver,
- Holly E. Baum,
- Kapil Gupta,
- Kathryn L. Shelley,
- Anna E. Long,
- Hayley E. Jones,
- Joyce Smith,
- Benjamin Hitchings,
- Natalie di Bartolo,
- Kate Vasileiou,
- Fruzsina Rabi,
- Hanin Alamir,
- Malak Eghleilib,
- Ore Francis,
- Jennifer Oliver,
- Begonia Morales-Aza,
- Ulrike Obst,
- Debbie Shattock,
- Rachael Barr,
- Lucy Collingwood,
- Kaltun Duale,
- Niall Grace,
- Guillaume Gonnage Livera,
- Lindsay Bishop,
- Harriet Downing,
- Fernanda Rodrigues,
- Nicholas Timpson,
- Caroline L. Relton,
- Ashley Toye,
- Derek N. Woolfson,
- Imre Berger,
- Anu Goenka,
- Andrew D. Davidson,
- Kathleen M. Gillespie,
- Alistair J. K. Williams,
- Mick Bailey,
- Ellen Brooks-Pollock,
- Adam Finn,
- Alice Halliday,
- the CoMMinS Study Team
Affiliations
- Amy C. Thomas
- Population Health Sciences, Bristol Medical School, University of Bristol
- Elizabeth Oliver
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Holly E. Baum
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Kapil Gupta
- School of Biochemistry, University of Bristol
- Kathryn L. Shelley
- School of Biochemistry, University of Bristol
- Anna E. Long
- Translational Health Sciences, Bristol Medical School, University of Bristol
- Hayley E. Jones
- Population Health Sciences, Bristol Medical School, University of Bristol
- Joyce Smith
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Benjamin Hitchings
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Natalie di Bartolo
- School of Biochemistry, University of Bristol
- Kate Vasileiou
- School of Biochemistry, University of Bristol
- Fruzsina Rabi
- School of Biochemistry, University of Bristol
- Hanin Alamir
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Malak Eghleilib
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Ore Francis
- Bristol Veterinary School, University of Bristol
- Jennifer Oliver
- Bristol Vaccine Centre, Population Health Sciences, University of Bristol
- Begonia Morales-Aza
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Ulrike Obst
- School of Cellular and Molecular Medicine, University of Bristol
- Debbie Shattock
- Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School, University of Bristol
- Rachael Barr
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Lucy Collingwood
- Bristol Vaccine Centre, Population Health Sciences, University of Bristol
- Kaltun Duale
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Niall Grace
- Bristol Vaccine Centre, Population Health Sciences, University of Bristol
- Guillaume Gonnage Livera
- Bristol Vaccine Centre, Population Health Sciences, University of Bristol
- Lindsay Bishop
- Bristol Vaccine Centre, Population Health Sciences, University of Bristol
- Harriet Downing
- NIHR Bristol Biomedical Research Centre, University of Bristol
- Fernanda Rodrigues
- Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra
- Nicholas Timpson
- Population Health Sciences, Bristol Medical School, University of Bristol
- Caroline L. Relton
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School
- Ashley Toye
- School of Biochemistry, University of Bristol
- Derek N. Woolfson
- School of Biochemistry, University of Bristol
- Imre Berger
- Max Planck Bristol Centre for Minimal Biology, University of Bristol
- Anu Goenka
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- Andrew D. Davidson
- School of Cellular and Molecular Medicine, University of Bristol
- Kathleen M. Gillespie
- Translational Health Sciences, Bristol Medical School, University of Bristol
- Alistair J. K. Williams
- Translational Health Sciences, Bristol Medical School, University of Bristol
- Mick Bailey
- Bristol Veterinary School, University of Bristol
- Ellen Brooks-Pollock
- Population Health Sciences, Bristol Medical School, University of Bristol
- Adam Finn
- Population Health Sciences, Bristol Medical School, University of Bristol
- Alice Halliday
- Bristol Vaccine Centre, School of Cellular and Molecular Medicine, University of Bristol
- the CoMMinS Study Team
- DOI
- https://doi.org/10.1038/s43856-023-00264-2
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 14
Abstract
Thomas et al. test 6 ELISAs detecting IgA and IgG antibodies to whole SARS-CoV-2 spike protein, to its receptor binding domain region and to nucleocapsid protein in saliva. Across 20 household outbreaks, antibody responses are heterogeneous, but a reliable indicator of recent infection.
