Nature Communications (Jan 2022)
Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities
- Nicola Cosgrove,
- Damir Varešlija,
- Stephen Keelan,
- Ashuvinee Elangovan,
- Jennifer M. Atkinson,
- Sinéad Cocchiglia,
- Fiona T. Bane,
- Vikrant Singh,
- Simon Furney,
- Chunling Hu,
- Jodi M. Carter,
- Steven N. Hart,
- Siddhartha Yadav,
- Matthew P. Goetz,
- Arnold D. K. Hill,
- Steffi Oesterreich,
- Adrian V. Lee,
- Fergus J. Couch,
- Leonie S. Young
Affiliations
- Nicola Cosgrove
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Damir Varešlija
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Stephen Keelan
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Ashuvinee Elangovan
- WCRC, UPMC Hillman Cancer Center, Magee-Womens Research Institute, University of Pittsburgh
- Jennifer M. Atkinson
- WCRC, UPMC Hillman Cancer Center, Magee-Womens Research Institute, University of Pittsburgh
- Sinéad Cocchiglia
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Fiona T. Bane
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Vikrant Singh
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Simon Furney
- Genomic Oncology Research Group, Royal College of Surgeons in Ireland
- Chunling Hu
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Jodi M. Carter
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Steven N. Hart
- Department of Quantitative Sciences Research, Mayo Clinic
- Siddhartha Yadav
- Department of Oncology, Mayo Clinic
- Matthew P. Goetz
- Department of Oncology, Mayo Clinic
- Arnold D. K. Hill
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- Steffi Oesterreich
- WCRC, UPMC Hillman Cancer Center, Magee-Womens Research Institute, University of Pittsburgh
- Adrian V. Lee
- WCRC, UPMC Hillman Cancer Center, Magee-Womens Research Institute, University of Pittsburgh
- Fergus J. Couch
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Leonie S. Young
- Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences
- DOI
- https://doi.org/10.1038/s41467-022-27987-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous recombination deficiency as a key therapeutic vulnerability.
