Nature Communications (Nov 2017)
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
- Jordi Sintes,
- Maurizio Gentile,
- Shuling Zhang,
- Yolanda Garcia-Carmona,
- Giuliana Magri,
- Linda Cassis,
- Daniel Segura-Garzón,
- Alessandra Ciociola,
- Emilie K. Grasset,
- Sabrina Bascones,
- Laura Comerma,
- Marc Pybus,
- David Lligé,
- Irene Puga,
- Cindy Gutzeit,
- Bing He,
- Wendy DuBois,
- Marta Crespo,
- Julio Pascual,
- Anna Mensa,
- Juan Ignacio Aróstegui,
- Manel Juan,
- Jordi Yagüe,
- Sergi Serrano,
- Josep Lloreta,
- Eric Meffre,
- Michael Hahne,
- Charlotte Cunningham-Rundles,
- Beverly A. Mock,
- Andrea Cerutti
Affiliations
- Jordi Sintes
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Maurizio Gentile
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Shuling Zhang
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
- Yolanda Garcia-Carmona
- Department of Medicine and Pediatrics, Immunology Institute, Icahn School of Medicine at Mount Sinai
- Giuliana Magri
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Linda Cassis
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Daniel Segura-Garzón
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Alessandra Ciociola
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Emilie K. Grasset
- Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai
- Sabrina Bascones
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Laura Comerma
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Marc Pybus
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- David Lligé
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Irene Puga
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Cindy Gutzeit
- Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai
- Bing He
- Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai
- Wendy DuBois
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
- Marta Crespo
- Department of Nephrology, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Julio Pascual
- Department of Nephrology, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Anna Mensa
- Immunology Service, Hospital Clínic of Barcelona
- Juan Ignacio Aróstegui
- Immunology Service, Hospital Clínic of Barcelona
- Manel Juan
- Immunology Service, Hospital Clínic of Barcelona
- Jordi Yagüe
- Immunology Service, Hospital Clínic of Barcelona
- Sergi Serrano
- Department of Pathology, Hospital del Mar
- Josep Lloreta
- Department of Pathology, Hospital del Mar
- Eric Meffre
- Department of Immunobiology, Yale University
- Michael Hahne
- Molecular Genetics Institute of Montpellier
- Charlotte Cunningham-Rundles
- Department of Medicine and Pediatrics, Immunology Institute, Icahn School of Medicine at Mount Sinai
- Beverly A. Mock
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
- Andrea Cerutti
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- DOI
- https://doi.org/10.1038/s41467-017-01602-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.
