Nature Communications (Apr 2016)
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
- Qiupeng Zheng,
- Chunyang Bao,
- Weijie Guo,
- Shuyi Li,
- Jie Chen,
- Bing Chen,
- Yanting Luo,
- Dongbin Lyu,
- Yan Li,
- Guohai Shi,
- Linhui Liang,
- Jianren Gu,
- Xianghuo He,
- Shenglin Huang
Affiliations
- Qiupeng Zheng
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Chunyang Bao
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Weijie Guo
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Shuyi Li
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Jie Chen
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Bing Chen
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Yanting Luo
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Dongbin Lyu
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Yan Li
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Guohai Shi
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Linhui Liang
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Jianren Gu
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Xianghuo He
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- Shenglin Huang
- Fudan University; Department of Oncology, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
- DOI
- https://doi.org/10.1038/ncomms11215
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Circular RNAs are formed from exon back-splicing, the significance of these endogenous RNAs is beginning to be unraveled. Here, the authors identify thousands of circular RNAs differentially expressed between normal and cancer tissues and show that an abundant circular RNA generated from HIPK3regulates cell growth.
