Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Reut Yosef; Noam Pilpel; Ronit Tokarsky-Amiel; Anat Biran; Yossi Ovadya; Snir Cohen; Ezra Vadai; Liat Dassa; Elisheva Shahar; Reba Condiotti; Ittai Ben-Porath; Valery Krizhanovsky

doi:10.1038/ncomms11190

Nature Communications (Apr 2016)

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Reut Yosef,
Noam Pilpel,
Ronit Tokarsky-Amiel,
Anat Biran,
Yossi Ovadya,
Snir Cohen,
Ezra Vadai,
Liat Dassa,
Elisheva Shahar,
Reba Condiotti,
Ittai Ben-Porath,
Valery Krizhanovsky

Affiliations

Reut Yosef: Department of Molecular Cell Biology, The Weizmann Institute of Science
Noam Pilpel: Department of Molecular Cell Biology, The Weizmann Institute of Science
Ronit Tokarsky-Amiel: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Anat Biran: Department of Molecular Cell Biology, The Weizmann Institute of Science
Yossi Ovadya: Department of Molecular Cell Biology, The Weizmann Institute of Science
Snir Cohen: Department of Molecular Cell Biology, The Weizmann Institute of Science
Ezra Vadai: Department of Molecular Cell Biology, The Weizmann Institute of Science
Liat Dassa: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Elisheva Shahar: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Reba Condiotti: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Ittai Ben-Porath: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
Valery Krizhanovsky: Department of Molecular Cell Biology, The Weizmann Institute of Science

DOI: https://doi.org/10.1038/ncomms11190
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell elimination in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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