Nature Communications (Apr 2022)
Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
- Mengci Li,
- Shouli Wang,
- Yitao Li,
- Mingliang Zhao,
- Junliang Kuang,
- Dandan Liang,
- Jieyi Wang,
- Meilin Wei,
- Cynthia Rajani,
- Xinran Ma,
- Yajun Tang,
- Zhenxing Ren,
- Tianlu Chen,
- Aihua Zhao,
- Cheng Hu,
- Chengxing Shen,
- Weiping Jia,
- Ping Liu,
- Xiaojiao Zheng,
- Wei Jia
Affiliations
- Mengci Li
- School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University
- Shouli Wang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yitao Li
- School of Chinese Medicine, Hong Kong Baptist University
- Mingliang Zhao
- School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University
- Junliang Kuang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Dandan Liang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jieyi Wang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Meilin Wei
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Cynthia Rajani
- University of Hawaii Cancer Center
- Xinran Ma
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
- Yajun Tang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhenxing Ren
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Tianlu Chen
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Aihua Zhao
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Cheng Hu
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Chengxing Shen
- Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Weiping Jia
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Ping Liu
- School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University
- Xiaojiao Zheng
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Wei Jia
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-022-29589-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Caloric restriction is a common approach to weight reduction, however, weight regain is common. Here the authors report that caloric restriction reduces the abundance of Parabacteroides distasonis in the gut and alters serum bile acid (BA) profile, which contribute to weight regain in mice.
