Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map

Dinu F. Albeanu; Allison C. Provost; Prateek Agarwal; Edward R. Soucy; Joseph D. Zak; Venkatesh N. Murthy

doi:10.1038/s41467-018-07544-9

Nature Communications (Nov 2018)

Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map

Dinu F. Albeanu,
Allison C. Provost,
Prateek Agarwal,
Edward R. Soucy,
Joseph D. Zak,
Venkatesh N. Murthy

Affiliations

Dinu F. Albeanu: Cold Spring Harbor Laboratory, Cold Spring Harbor
Allison C. Provost: Department of Molecular and Cellular Biology, Harvard University
Prateek Agarwal: Department of Molecular and Cellular Biology, Harvard University
Edward R. Soucy: Department of Molecular and Cellular Biology, Harvard University
Joseph D. Zak: Department of Molecular and Cellular Biology, Harvard University
Venkatesh N. Murthy: Department of Molecular and Cellular Biology, Harvard University

DOI: https://doi.org/10.1038/s41467-018-07544-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Olfactory marker protein (OMP) expressed in all olfactory sensory neurons (OSN) is required for proper signal transduction and odor discrimination. Here, the authors report that OMP deletion leads to formation of glomeruli with axons from heterogeneous OSNs due to local axonal mistargeting.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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