Nature Communications (Sep 2022)
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance
- Xu Zhang,
- Vesselina M. Pearsall,
- Chase M. Carver,
- Elizabeth J. Atkinson,
- Benjamin D. S. Clarkson,
- Ethan M. Grund,
- Michelle Baez-Faria,
- Kevin D. Pavelko,
- Jennifer M. Kachergus,
- Thomas A. White,
- Renee K. Johnson,
- Courtney S. Malo,
- Alan M. Gonzalez-Suarez,
- Katayoun Ayasoufi,
- Kurt O. Johnson,
- Zachariah P. Tritz,
- Cori E. Fain,
- Roman H. Khadka,
- Mikolaj Ogrodnik,
- Diana Jurk,
- Yi Zhu,
- Tamara Tchkonia,
- Alexander Revzin,
- James L. Kirkland,
- Aaron J. Johnson,
- Charles L. Howe,
- E. Aubrey Thompson,
- Nathan K. LeBrasseur,
- Marissa J. Schafer
Affiliations
- Xu Zhang
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Vesselina M. Pearsall
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Chase M. Carver
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- Elizabeth J. Atkinson
- Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic
- Benjamin D. S. Clarkson
- Department of Neurology, Mayo Clinic
- Ethan M. Grund
- Mayo Graduate School and Medical Scientist Training Program, Mayo Clinic
- Michelle Baez-Faria
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- Kevin D. Pavelko
- Department of Immunology, Mayo Clinic
- Jennifer M. Kachergus
- Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic
- Thomas A. White
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Renee K. Johnson
- Department of Neurology, Mayo Clinic
- Courtney S. Malo
- Department of Immunology, Mayo Clinic
- Alan M. Gonzalez-Suarez
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- Katayoun Ayasoufi
- Department of Immunology, Mayo Clinic
- Kurt O. Johnson
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Zachariah P. Tritz
- Department of Immunology, Mayo Clinic
- Cori E. Fain
- Department of Immunology, Mayo Clinic
- Roman H. Khadka
- Department of Immunology, Mayo Clinic
- Mikolaj Ogrodnik
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Diana Jurk
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Yi Zhu
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Tamara Tchkonia
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Alexander Revzin
- Department of Physiology and Biomedical Engineering, Mayo Clinic
- James L. Kirkland
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Aaron J. Johnson
- Department of Immunology, Mayo Clinic
- Charles L. Howe
- Department of Neurology, Mayo Clinic
- E. Aubrey Thompson
- Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic
- Nathan K. LeBrasseur
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- Marissa J. Schafer
- Robert and Arlene Kogod Center on Aging, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-022-33226-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
