Nature Communications (Jul 2021)

Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects

  • Xing Jian,
  • Gary Felsenfeld

DOI
https://doi.org/10.1038/s41467-021-24635-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

A SNP distant from the human insulin (INS) gene near the KRTAP5-6 gene confers increased susceptibility to type 2 diabetes when present on the paternal allele while decreased susceptibility when on the maternal allele. Here the authors show that long-range contacts between the INS locus and the KRTAP5-6 gene locus distinguish paternal and maternal alleles.