Nature Communications (May 2022)
Serum metabolome associated with severity of acute traumatic brain injury
- Ilias Thomas,
- Alex M. Dickens,
- Jussi P. Posti,
- Endre Czeiter,
- Daniel Duberg,
- Tim Sinioja,
- Matilda Kråkström,
- Isabel R. A. Retel Helmrich,
- Kevin K. W. Wang,
- Andrew I. R. Maas,
- Ewout W. Steyerberg,
- David K. Menon,
- Olli Tenovuo,
- Tuulia Hyötyläinen,
- András Büki,
- Matej Orešič,
- CENTER-TBI Participants and Investigators
Affiliations
- Ilias Thomas
- School of Medical Sciences, Örebro University
- Alex M. Dickens
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Jussi P. Posti
- Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku
- Endre Czeiter
- Department of Neurosurgery, Medical School, University of Pécs
- Daniel Duberg
- Department of Chemistry, Örebro University
- Tim Sinioja
- Department of Chemistry, Örebro University
- Matilda Kråkström
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Isabel R. A. Retel Helmrich
- Department of Public Health, Center for Medical Decision Making, Erasmus MC-University Medical Center
- Kevin K. W. Wang
- Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Emergency Medicine, McKnight Brin Institute of the University of Florida
- Andrew I. R. Maas
- Department of Neurosurgery, Antwerp University Hospital and University of Antwerp
- Ewout W. Steyerberg
- Department of Public Health, Center for Medical Decision Making, Erasmus MC-University Medical Center
- David K. Menon
- Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital
- Olli Tenovuo
- Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku
- Tuulia Hyötyläinen
- Department of Chemistry, Örebro University
- András Büki
- School of Medical Sciences, Örebro University
- Matej Orešič
- School of Medical Sciences, Örebro University
- CENTER-TBI Participants and Investigators
- DOI
- https://doi.org/10.1038/s41467-022-30227-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Traumatic brain injury is associated with changes to the metabolome. Here the authors show that acute traumatic brain injury has distinctive serum metabolic patterns which may suggest protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.
