Nature Communications (Jun 2019)
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
- Dongwon Kim,
- Ruosi Chen,
- Mary Sheu,
- Noori Kim,
- Sooah Kim,
- Nasif Islam,
- Eric M. Wier,
- Gaofeng Wang,
- Ang Li,
- Angela Park,
- Wooyang Son,
- Benjamin Evans,
- Victoria Yu,
- Vicky P. Prizmic,
- Eugene Oh,
- Zixiao Wang,
- Jianshi Yu,
- Weiliang Huang,
- Nathan K. Archer,
- Zhiqi Hu,
- Nashay Clemetson,
- Amanda M. Nelson,
- Anna Chien,
- Ginette A. Okoye,
- Lloyd S. Miller,
- Gabriel Ghiaur,
- Sewon Kang,
- Jace W. Jones,
- Maureen A. Kane,
- Luis A. Garza
Affiliations
- Dongwon Kim
- Department of Dermatology, Johns Hopkins University School of Medicine
- Ruosi Chen
- Department of Dermatology, Johns Hopkins University School of Medicine
- Mary Sheu
- Department of Dermatology, Johns Hopkins University School of Medicine
- Noori Kim
- Department of Dermatology, Johns Hopkins University School of Medicine
- Sooah Kim
- Department of Dermatology, Johns Hopkins University School of Medicine
- Nasif Islam
- Department of Dermatology, Johns Hopkins University School of Medicine
- Eric M. Wier
- Department of Dermatology, Johns Hopkins University School of Medicine
- Gaofeng Wang
- Department of Dermatology, Johns Hopkins University School of Medicine
- Ang Li
- Department of Dermatology, Johns Hopkins University School of Medicine
- Angela Park
- Department of Dermatology, Johns Hopkins University School of Medicine
- Wooyang Son
- Department of Dermatology, Johns Hopkins University School of Medicine
- Benjamin Evans
- Department of Dermatology, Johns Hopkins University School of Medicine
- Victoria Yu
- Department of Dermatology, Johns Hopkins University School of Medicine
- Vicky P. Prizmic
- Department of Dermatology, Johns Hopkins University School of Medicine
- Eugene Oh
- Department of Dermatology, Johns Hopkins University School of Medicine
- Zixiao Wang
- Department of Dermatology, Johns Hopkins University School of Medicine
- Jianshi Yu
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland
- Weiliang Huang
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland
- Nathan K. Archer
- Department of Dermatology, Johns Hopkins University School of Medicine
- Zhiqi Hu
- Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University
- Nashay Clemetson
- Department of Dermatology, Johns Hopkins University School of Medicine
- Amanda M. Nelson
- Department of Dermatology, College of Medicine, The Pennsylvania State University
- Anna Chien
- Department of Dermatology, Johns Hopkins University School of Medicine
- Ginette A. Okoye
- Department of Dermatology, Johns Hopkins University School of Medicine
- Lloyd S. Miller
- Department of Dermatology, Johns Hopkins University School of Medicine
- Gabriel Ghiaur
- Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine
- Sewon Kang
- Department of Dermatology, Johns Hopkins University School of Medicine
- Jace W. Jones
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland
- Maureen A. Kane
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland
- Luis A. Garza
- Department of Dermatology, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10811-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells.
