Nature Communications (Jun 2018)
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
- Yoonmi Lee,
- Nam Hee Kim,
- Eunae Sandra Cho,
- Ji Hye Yang,
- Yong Hoon Cha,
- Hee Eun Kang,
- Jun Seop Yun,
- Sue Bean Cho,
- Seon-Hyeong Lee,
- Petra Paclikova,
- Tomasz W. Radaszkiewicz,
- Vitezslav Bryja,
- Chi Gu Kang,
- Young Soo Yuk,
- So Young Cha,
- Soo-Youl Kim,
- Hyun Sil Kim,
- Jong In Yook
Affiliations
- Yoonmi Lee
- Department of Oral Pathology, Yonsei University College of Dentistry
- Nam Hee Kim
- Oral Cancer Research Institute, Yonsei University College of Dentistry
- Eunae Sandra Cho
- Department of Oral Pathology, Yonsei University College of Dentistry
- Ji Hye Yang
- Department of Oral Pathology, Yonsei University College of Dentistry
- Yong Hoon Cha
- Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry
- Hee Eun Kang
- Department of Oral Pathology, Yonsei University College of Dentistry
- Jun Seop Yun
- Department of Oral Pathology, Yonsei University College of Dentistry
- Sue Bean Cho
- Oral Cancer Research Institute, Yonsei University College of Dentistry
- Seon-Hyeong Lee
- Cancer Cell and Molecular Biology Branch, National Cancer Center
- Petra Paclikova
- Institute of Experimental Biology, Faculty of Science, Masaryk University
- Tomasz W. Radaszkiewicz
- Institute of Experimental Biology, Faculty of Science, Masaryk University
- Vitezslav Bryja
- Institute of Experimental Biology, Faculty of Science, Masaryk University
- Chi Gu Kang
- Department of Oral Pathology, Yonsei University College of Dentistry
- Young Soo Yuk
- Department of Oral Pathology, Yonsei University College of Dentistry
- So Young Cha
- Department of Oral Pathology, Yonsei University College of Dentistry
- Soo-Youl Kim
- Cancer Cell and Molecular Biology Branch, National Cancer Center
- Hyun Sil Kim
- Oral Cancer Research Institute, Yonsei University College of Dentistry
- Jong In Yook
- Department of Oral Pathology, Yonsei University College of Dentistry
- DOI
- https://doi.org/10.1038/s41467-018-04757-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts.
