Nature Communications (Sep 2018)

Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding

  • Emma Lång,
  • Anna Połeć,
  • Anna Lång,
  • Marijke Valk,
  • Pernille Blicher,
  • Alexander D. Rowe,
  • Kim A. Tønseth,
  • Catherine J. Jackson,
  • Tor P. Utheim,
  • Liesbeth M. C. Janssen,
  • Jens Eriksson,
  • Stig Ove Bøe

DOI
https://doi.org/10.1038/s41467-018-05578-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Epithelial sheet migration requires polarized and coordinated cell movement. Here, the authors demonstrate serum-activated collective migration followed by polarized asymmetric cell divisions in otherwise quiescent human keratinocyte monolayers in the absence of wound edges.