Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Chao Zhang; Cong Xu; Wenlong Dai; Yifan Wang; Zhi Liu; Xueyang Zhang; Xuesong Wang; Haikun Wang; Sitang Gong; Yao Cong; Zhong Huang

doi:10.1038/s41467-021-23199-5

Nature Communications (May 2021)

Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

Chao Zhang,
Cong Xu,
Wenlong Dai,
Yifan Wang,
Zhi Liu,
Xueyang Zhang,
Xuesong Wang,
Haikun Wang,
Sitang Gong,
Yao Cong,
Zhong Huang

Affiliations

Chao Zhang: Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
Cong Xu: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Wenlong Dai: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yifan Wang: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Zhi Liu: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Xueyang Zhang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Xuesong Wang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Haikun Wang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Sitang Gong: Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
Yao Cong: State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Zhong Huang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-23199-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Although enterovirus D68 poses a major global threat to children, neither vaccines nor therapeutics are currently available. Using Cryo-EM, Zhang et al. show that two murine-derived monoclonal antibodies with therapeutic efficacy neutralize virions via binding to the canyon region, creating steric hindrance for sialic acid receptor binding.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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