Novel azapropazone voltammetric sensors based on zinc oxide nanostructure

Abstract

Azapropazone (AZA) is anti-inflammatory drug for treatment of arthritic conditions with low side effect. The construction and electroanalytical uses of brand-new AZA voltammetric sensor are demonstrated. Working carbon paste electrodes integrated with 5.0% ZnONPs exhibited proper catalytic effect toward oxidation of AZA molecule. At pH 5.0, AZA recorded single irreversible anodic oxidation at 0.462 V. Based on CV registered at variable conditions, oxidation of AZA molecule by one proton and two electrons of N16 with de-localized lone pair of electrons. Calibration graphs showed good linearity within AZA concentration from 19.5 to 1040.75 ng mL−1 with LOD and LOQ values of 1.67 and 5.6 ng mL−1. The presented sensor showed improved LOQ and LOD values. Also, electrooxidation mechanism of AZA molecule and EIS of sensors were reported. The proposed analytical approach was examined for sensitive voltammetric determination of azapropazone in pharmaceutical formulations and biological fluids with agreeable recoveries.

Keywords

• Azapropazone sensor
• nano zinc oxide
• differential pulse voltammetry
• oxidation mechanism
• biological samples