Molecules (Feb 2022)

Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice

  • Areej Al-Qahtani,
  • Jamaan Ajarem,
  • Mohammad K. Okla,
  • Samina Rubnawaz,
  • Saud A. Alamri,
  • Wahidah H. Al-Qahtani,
  • Ahmad R. Al-Himaidi,
  • Hamada Abd Elgawad,
  • Nosheen Akhtar,
  • Saleh N. Maodaa,
  • Mostafa A. Abdel-Maksoud

DOI
https://doi.org/10.3390/molecules27030993
Journal volume & issue
Vol. 27, no. 3
p. 993

Abstract

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The use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiving group; C: lead-intoxicated group; and D: lead-intoxicated group supplemented with green tea. At the end of the experiment, the animals were tested for neurobehavioral and biochemical alterations. Green tea was analyzed through Gas Chromatography–Mass Spectrometry (GC/MS) analysis. We found that supplementation with green tea ameliorated the lead-associated increase in body weight and blood glucose. Green tea supplementation also changed the blood picture that was affected due to lead toxicity and ameliorated lead-induced dyslipidemia. The group of mice that were supplemented with green tea has shown positive alterations in locomotory, anxiety, memory, and learning behaviors. The GC/MS analysis revealed many active ingredients among which the two most abundant were caffeine and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester. We concluded that green tea supplementation has several positive effects on the lead-induced neurotoxicity in mice and that these effects may be attributed to its main two active ingredients.

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