Science & Research (Feb 2022)
MULTIPLE SCLEROSIS: ASSESSMENT OF RETINAL MICROSTRUCTURE BY OPTICAL COHERENCE TOMOGRAPHY
Abstract
Aims: To measure the thickness of the peripapillary neurofibrillary layer of the retina (pRNFL) and the volume of the macula in patients with multiple sclerosis (MS), and to compare them with those in healthy volunteers. Study design: prospective pilot study Methods: In this prospective pilot study, a total of 40 eyes were examined: twenty eyes of ten patients with multiple sclerosis and twenty eyes of ten healthy volunteers of the same age without eye or systemic disease. A complete eye examination was performed, including visual acuity with the best correction, refraction, color vision test, and intraocular pressure. Optical coherence tomography (OCT) was performed with 3D Topcon 2000FA + OCT, measuring and comparing the retinal neurofibrillary parameters (pRNFL) and macular volume in all eyes. Results: OCT studies revealed changes in pRNFL thickness and macular volume in patients with multiple sclerosis. Conclusion: Patients with MS show thinning of pRNFL and reduction of macular volume - changes that are indicative of the course of neurodegeneration throughout the body.
