ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria

Alexander Mühleip; Rasmus Kock Flygaard; Jana Ovciarikova; Alice Lacombe; Paula Fernandes; Lilach Sheiner; Alexey Amunts

doi:10.1038/s41467-020-20381-z

Nature Communications (Jan 2021)

ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria

Alexander Mühleip,
Rasmus Kock Flygaard,
Jana Ovciarikova,
Alice Lacombe,
Paula Fernandes,
Lilach Sheiner,
Alexey Amunts

Affiliations

Alexander Mühleip: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
Rasmus Kock Flygaard: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
Jana Ovciarikova: Wellcome Centre for Integrative Parasitology, University of Glasgow
Alice Lacombe: Wellcome Centre for Integrative Parasitology, University of Glasgow
Paula Fernandes: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
Lilach Sheiner: Wellcome Centre for Integrative Parasitology, University of Glasgow
Alexey Amunts: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University

DOI: https://doi.org/10.1038/s41467-020-20381-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Structural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morphology in Apicomplexa.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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