Nature Communications (Mar 2022)
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
- Astros Th. Skuladottir,
- Gyda Bjornsdottir,
- Egil Ferkingstad,
- Gudmundur Einarsson,
- Lilja Stefansdottir,
- Muhammad Sulaman Nawaz,
- Asmundur Oddsson,
- Thorunn A. Olafsdottir,
- Saedis Saevarsdottir,
- G. Bragi Walters,
- Sigurdur H. Magnusson,
- Anna Bjornsdottir,
- Olafur A. Sveinsson,
- Arnor Vikingsson,
- Thomas Folkmann Hansen,
- Rikke Louise Jacobsen,
- Christian Erikstrup,
- Michael Schwinn,
- Søren Brunak,
- Karina Banasik,
- Sisse Rye Ostrowski,
- Anders Troelsen,
- Cecilie Henkel,
- Ole Birger Pedersen,
- DBDS Genetic Consortium,
- Ingileif Jonsdottir,
- Daniel F. Gudbjartsson,
- Patrick Sulem,
- Thorgeir E. Thorgeirsson,
- Hreinn Stefansson,
- Kari Stefansson
Affiliations
- Astros Th. Skuladottir
- deCODE genetics/Amgen Inc.
- Gyda Bjornsdottir
- deCODE genetics/Amgen Inc.
- Egil Ferkingstad
- deCODE genetics/Amgen Inc.
- Gudmundur Einarsson
- deCODE genetics/Amgen Inc.
- Lilja Stefansdottir
- deCODE genetics/Amgen Inc.
- Muhammad Sulaman Nawaz
- deCODE genetics/Amgen Inc.
- Asmundur Oddsson
- deCODE genetics/Amgen Inc.
- Thorunn A. Olafsdottir
- deCODE genetics/Amgen Inc.
- Saedis Saevarsdottir
- deCODE genetics/Amgen Inc.
- G. Bragi Walters
- deCODE genetics/Amgen Inc.
- Sigurdur H. Magnusson
- deCODE genetics/Amgen Inc.
- Anna Bjornsdottir
- Heilsuklasinn Clinic
- Olafur A. Sveinsson
- Faculty of Medicine, University of Iceland
- Arnor Vikingsson
- Landspitali—the National University Hospital of Iceland
- Thomas Folkmann Hansen
- Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet—Glostrup
- Rikke Louise Jacobsen
- Department of Clinical Immunology, Copenhagen University Hospital—Rigshospitalet
- Christian Erikstrup
- Department of Clinical Immunology, Aarhus University Hospital
- Michael Schwinn
- Department of Clinical Immunology, Copenhagen University Hospital—Rigshospitalet
- Søren Brunak
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Karina Banasik
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Sisse Rye Ostrowski
- Department of Clinical Immunology, Copenhagen University Hospital—Rigshospitalet
- Anders Troelsen
- Department of Orthopaedic Surgery, CAG ROAD - Research OsteoArthritis Denmark, Copenhagen University Hospital
- Cecilie Henkel
- Department of Orthopaedic Surgery, CORH, Copenhagen University Hospital
- Ole Birger Pedersen
- Department of Clinical Immunology, Zealand University Hospital—Køge
- DBDS Genetic Consortium
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Patrick Sulem
- deCODE genetics/Amgen Inc.
- Thorgeir E. Thorgeirsson
- deCODE genetics/Amgen Inc.
- Hreinn Stefansson
- deCODE genetics/Amgen Inc.
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s41467-022-29133-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
The underlying genetics of carpal tunnel syndrome is not well understood. Here, the authors perform a GWAS meta-analysis for carpal tunnel syndrome finding variants at 50 loci with connections to the extracellular matrix discovered through various functional analyses.
