Nature Communications (Sep 2017)

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

  • Anil Rana,
  • Matheus P. Oliveira,
  • Andy V. Khamoui,
  • Ricardo Aparicio,
  • Michael Rera,
  • Harry B. Rossiter,
  • David W. Walker

DOI
https://doi.org/10.1038/s41467-017-00525-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Mitochondrial fission and fusion are important mechanisms to maintain mitochondrial function. Here, the authors report that middle-aged flies have more elongated, or ‘hyper-fused’ mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life, extends the health and life of flies.