The prevalence of parenteral hepatitis markers among the medical personnel in the Russian Federation regions with different intensity of epidemic process

Abstract

The results of hepatitis markers prevalence estimation and the immune response intensity and duration in hospital staff (Buryatiya, Ulan-Ude, n=611 and Moscow, n=653) after vaccination against hepatitis B are presented. HBV serological markers were revealed in 259 (42.5%) and 70 (11.7%) persons: HBsAg (2.6% versus 0.2%; p<0.05), anti-HBs in a combination with anti-HBc (35.0% versus 10.7%; p<0.05), only anti-HBc (4.9% versus 0.8%; p<0.05) among Ulan-Ude and Moscow medical personnel, respectively. HBV DNA positive in PCR isolates had genotype D (90.9%), subtypes ayw3 and ayw2. HBV genotype D has been established in 90.9% of isolates and genotype A in 9.1% (Ulan-Ude). Prevalence of subtypes HBsAg in our research was 9.1% (ad) and (90.9% (ay). Anti-HCV were revealed in 3.3% and 2.9%, HCV RNA – in 41.2% and 36.8%, genotype 1 HCV – in 57.1% and 85.7%, genotype 3 HCV in 28.6% and 14.3% of cases in Ulan-Ude and Moscow, respectively. The question of the selection of vaccines with dominant among the population of Russia HBsAg subtype ay for the improvement of immunization programs is discussed.

Keywords

• hospital staff
• vaccination
• hepatitis b
• hepatitis c
• hbsag subtypes