Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage

Kang Wang; Ling Zhu; Yao Sun; Minhao Li; Xin Zhao; Lunbiao Cui; Li Zhang; George F. Gao; Weiwei Zhai; Fengcai Zhu; Zihe Rao; Xiangxi Wang

doi:10.1038/s41467-020-18251-9

Nature Communications (Sep 2020)

Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage

Kang Wang,
Ling Zhu,
Yao Sun,
Minhao Li,
Xin Zhao,
Lunbiao Cui,
Li Zhang,
George F. Gao,
Weiwei Zhai,
Fengcai Zhu,
Zihe Rao,
Xiangxi Wang

Affiliations

Kang Wang: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ling Zhu: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yao Sun: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Minhao Li: Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences
Xin Zhao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Lunbiao Cui: NHC Key Laboratories of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention
Li Zhang: NHC Key Laboratories of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention
George F. Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Weiwei Zhai: Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences
Fengcai Zhu: NHC Key Laboratories of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention
Zihe Rao: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiangxi Wang: CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-18251-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Echovirus 30 (E30) belongs to the Enterovirus-B group and causes aseptic meningitis in humans. Here, the authors present the cryo-EM structures of the E30 E-particle, A-particle and the mature virion, as well as structures of E30 in complex with its receptor FcRn and CD55, and furthermore they describe a structure-based algorithm that allows the prediction of EV receptor usage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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