STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Jesse J. Balic; Hassan Albargy; Kevin Luu; Francis J. Kirby; W. Samantha N. Jayasekara; Finbar Mansell; Daniel J. Garama; Dominic De Nardo; Nikola Baschuk; Cynthia Louis; Fiachra Humphries; Katherine Fitzgerald; Eicke Latz; Daniel J. Gough; Ashley Mansell

doi:10.1038/s41467-020-17669-5

Nature Communications (Jul 2020)

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Jesse J. Balic,
Hassan Albargy,
Kevin Luu,
Francis J. Kirby,
W. Samantha N. Jayasekara,
Finbar Mansell,
Daniel J. Garama,
Dominic De Nardo,
Nikola Baschuk,
Cynthia Louis,
Fiachra Humphries,
Katherine Fitzgerald,
Eicke Latz,
Daniel J. Gough,
Ashley Mansell

Affiliations

Jesse J. Balic: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Hassan Albargy: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Kevin Luu: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Francis J. Kirby: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
W. Samantha N. Jayasekara: Department of Molecular and Translational Sciences, Monash University
Finbar Mansell: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Daniel J. Garama: Department of Molecular and Translational Sciences, Monash University
Dominic De Nardo: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
Nikola Baschuk: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Cynthia Louis: Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
Fiachra Humphries: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School
Katherine Fitzgerald: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School
Eicke Latz: Institute of Innate Immunity, University Hospital Bonn, University of Bonn
Daniel J. Gough: Department of Molecular and Translational Sciences, Monash University
Ashley Mansell: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-020-17669-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a proinflammatory switch via an effect on mitochondrial metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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