Nature Communications (Jan 2020)

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

  • Yang Li,
  • Mingyou Zhang,
  • Xiaodan Wang,
  • Wentao Liu,
  • Hui Wang,
  • Yong-Guang Yang

DOI
https://doi.org/10.1038/s41467-019-14102-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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CD47 is expressed on tumour cells and binds to SIRPα, expressed on myeloid cells, preventing phagocytosis. Here, the authors show that injection of tumour cells lacking CD47, or cells coated with an anti-CD47 antibody, into mice mounts a strong immune response, resulting in a reduction in tumour growth.