Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation

Xiaoming Hu; Yuguo Niu; Peixiang Luo; Fei Xiao; Feixiang Yuan; Hanrui Yin; Shanghai Chen; Feifan Guo

doi:10.1038/s42003-022-03609-0

Communications Biology (Jul 2022)

Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation

Xiaoming Hu,
Yuguo Niu,
Peixiang Luo,
Fei Xiao,
Feixiang Yuan,
Hanrui Yin,
Shanghai Chen,
Feifan Guo

Affiliations

Xiaoming Hu: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Yuguo Niu: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Peixiang Luo: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Fei Xiao: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Feixiang Yuan: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Hanrui Yin: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Shanghai Chen: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University
Feifan Guo: Zhongshan Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University

DOI: https://doi.org/10.1038/s42003-022-03609-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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Amino acid deprivation increases ACE2 expression in the gut, potentially aggravating SARS-CoV-2 infection.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal