Mitochondria-targeted and pH-triggered charge-convertible polymeric micelles for anticancer therapy

Lingli Jin; Yanwen Xu; Fengjiao Chen; Dingle Yu; Hongze Liang; Zhenjiang Liang; Ziyu Liu, Dr; Haiyan Li; Junying Liu; Hui Tan; Lingling Zhao

Materials & Design (Dec 2022)

Mitochondria-targeted and pH-triggered charge-convertible polymeric micelles for anticancer therapy

Lingli Jin,
Yanwen Xu,
Fengjiao Chen,
Dingle Yu,
Hongze Liang,
Zhenjiang Liang,
Ziyu Liu, Dr,
Haiyan Li,
Junying Liu,
Hui Tan,
Lingling Zhao

Affiliations

Lingli Jin: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China; Respiratory Department, Shenzhen Children’s Hospital, Shenzhen 518038, China
Yanwen Xu: Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China
Fengjiao Chen: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China
Dingle Yu: Respiratory Department, Shenzhen Children’s Hospital, Shenzhen 518038, China
Hongze Liang: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China
Zhenjiang Liang: E.N.T. Department of Shenzhen Children's Hospital, Shenzhen 518026, China
Ziyu Liu, Dr: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China; Corresponding authors.
Haiyan Li: Department of Endocrinology, The First Affiliated Hospital, Shenzhen University, Shenzhen 518035, China
Junying Liu: Department of Endocrinology, The First Affiliated Hospital, Shenzhen University, Shenzhen 518035, China
Hui Tan: Respiratory Department, Shenzhen Children’s Hospital, Shenzhen 518038, China; Corresponding authors.
Lingling Zhao: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China; Corresponding authors.

Journal volume & issue: Vol. 224
p. 111290

Abstract

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Mitochondria-targeted and pH-triggered charge-convertible polymeric micelles (GPTD) were developed for doxorubicin (DOX) delivery and targeted anticancer therapy. GPTD surface was negatively charged under physiological pH (7.4), while it converted to positive charge under tumor pH (6.8). Sustained release of DOX from the drug loaded polymeric micelles was observed and the drug release was accelerated by decreasing the medium pH from 7.4 to 6.8. Cellular uptake by U251 glioma cells showed that GPTD can enhance the accumulation of polymeric micelles inside the mitochondria after charge-mediated cellular internalization and release DOX into the cellular interior. In vivo anticancer activity performed on glioma Balb/c nude mice demonstrated that the DOX-containing GPTD could remarkably inhibit the tumor growth, and displayed a significant reduction of tumor tissue cells and fewer Ki67 positive cells compared to the PBS group. Hence, this mitochondrial targeted and pH-triggered charge-convertible polymeric micellar system showed substantial promise for anticancer therapy.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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