Eletroforese capilar acoplada à espectrometria de massas (CE-MS): vinte anos de desenvolvimento Capillary electrophoresis coupled to mass spectrometry (CE-MS): twenty years of development

Abstract

CE-MS has been increasingly used for analysis of a vast array of compounds. This article reviews the different electrophoretic modes, interfaces and mass analyzers that are commonly used in the CE-MS coupling, as well as the technique advantages and performance characteristics. A large compilation of CE-MS applications is also presented. Therefore, this review is both a guide for beginners and a collection of key references for people who are familiar to the technique. Furthermore, this is the first CE-MS review published in a Brazilian journal and marks the installation of the first two commercial CE-MS units in Sao Paulo State.

Keywords

• capillary electrophoresis
• electrospray ionization
• mass spectrometry