Molecules (Aug 2015)

Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells

  • You Ah Kim,
  • Chang-Suk Kong,
  • Hyo Hyun Park,
  • Eunkyung Lee,
  • Mi-Soon Jang,
  • Ki-Ho Nam,
  • Youngwan Seo

DOI
https://doi.org/10.3390/molecules200814474
Journal volume & issue
Vol. 20, no. 8
pp. 14474 – 14486

Abstract

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The inhibitory effect of three chromones 1–3 and two coumarins 4–5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E2 (PGE2) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).

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