HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Patricia T. Illing; Phillip Pymm; Nathan P. Croft; Hugo G. Hilton; Vladimir Jojic; Alex S. Han; Juan L. Mendoza; Nicole A. Mifsud; Nadine L. Dudek; James McCluskey; Peter Parham; Jamie Rossjohn; Julian P. Vivian; Anthony W. Purcell

doi:10.1038/s41467-018-07109-w

Nature Communications (Nov 2018)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Patricia T. Illing,
Phillip Pymm,
Nathan P. Croft,
Hugo G. Hilton,
Vladimir Jojic,
Alex S. Han,
Juan L. Mendoza,
Nicole A. Mifsud,
Nadine L. Dudek,
James McCluskey,
Peter Parham,
Jamie Rossjohn,
Julian P. Vivian,
Anthony W. Purcell

Affiliations

Patricia T. Illing: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Phillip Pymm: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Nathan P. Croft: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Hugo G. Hilton: Departments of Structural Biology and Microbiology & Immunology, School of Medicine, Stanford University
Vladimir Jojic: Calico Life Sciences LLC
Alex S. Han: Department of Genetics, School of Medicine, Stanford University
Juan L. Mendoza: Department of Molecular and Cellular Physiology, School of Medicine, Stanford University
Nicole A. Mifsud: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Nadine L. Dudek: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
James McCluskey: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Peter Parham: Departments of Structural Biology and Microbiology & Immunology, School of Medicine, Stanford University
Jamie Rossjohn: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Julian P. Vivian: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Anthony W. Purcell: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/s41467-018-07109-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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