Nature Communications (May 2021)

Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke

  • Eckhard Schlemm,
  • Thies Ingwersen,
  • Alina Königsberg,
  • Florent Boutitie,
  • Martin Ebinger,
  • Matthias Endres,
  • Jochen B. Fiebach,
  • Jens Fiehler,
  • Ivana Galinovic,
  • Robin Lemmens,
  • Keith W. Muir,
  • Norbert Nighoghossian,
  • Salvador Pedraza,
  • Josep Puig,
  • Claus Z. Simonsen,
  • Vincent Thijs,
  • Anke Wouters,
  • Christian Gerloff,
  • Götz Thomalla,
  • Bastian Cheng

DOI
https://doi.org/10.1038/s41467-021-22786-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.