Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer

Abstract

Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2. We constructed and validated a novel prognostic signature based on seven unfolded protein response-related genes, which was an independent prognostic factors in bladder cancer. 3. We revealed the correlation between the prognostic signature and tumor immunosuppressive microenvironment. 4. We investigated the relationship between the prognostic signature and sensitivity of common chemotherapy drugs.

Keywords

• Unfolded protein response
• Bladder cancer
• Prognostic
• Biomarker