mBio (Feb 2021)
Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fc <b>γ</b> Receptor-Dependent and -Independent Pathways
- Lei Yu,
- Xinglong Liu,
- Xianmiao Ye,
- Wan Su,
- Xiaoyan Zhang,
- Weiqi Deng,
- Jia Luo,
- Mengrong Xiang,
- Wenjing Guo,
- Shengnan Zhang,
- Wei Xu,
- Qihong Yan,
- Qian Wang,
- Yilan Cui,
- Caixia Wu,
- Wenjing Guo,
- Xuefeng Niu,
- Fuchun Zhang,
- Chunliang Lei,
- Linbing Qu,
- Ling Chen,
- Liqiang Feng
Affiliations
- Lei Yu
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Xinglong Liu
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Xianmiao Ye
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Wan Su
- School of Biomedical Sciences, Huaqiao University, Quanzhou, China
- Xiaoyan Zhang
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Weiqi Deng
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Jia Luo
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Mengrong Xiang
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Wenjing Guo
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Shengnan Zhang
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Wei Xu
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Qihong Yan
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Qian Wang
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Yilan Cui
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Caixia Wu
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Wenjing Guo
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Xuefeng Niu
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Fuchun Zhang
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Chunliang Lei
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Linbing Qu
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- Ling Chen
- ORCiD
- Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China
- Liqiang Feng
- ORCiD
- State Key Laboratories of Respiratory Diseases, Guangdong Provincial Key Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
- DOI
- https://doi.org/10.1128/mBio.03179-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
Zika virus (ZIKV) is a mosquito-borne flavivirus that has been linked to congenital microcephaly during recent epidemics. No licensed antiviral drug or vaccine is available.
