Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep

Pawan K. Jha; Utham K. Valekunja; Sandipan Ray; Mathieu Nollet; Akhilesh B. Reddy

doi:10.1038/s42003-022-03800-3

Communications Biology (Aug 2022)

Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep

Pawan K. Jha,
Utham K. Valekunja,
Sandipan Ray,
Mathieu Nollet,
Akhilesh B. Reddy

Affiliations

Pawan K. Jha: Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Utham K. Valekunja: Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Sandipan Ray: Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Mathieu Nollet: Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Akhilesh B. Reddy: Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s42003-022-03800-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Joint scRNA-seq and proteomic analysis of the hypothalamus, cortex, and brainstem in mice provides insight into the cellular and molecular underpinnings of sleep homeostasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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