Relationship Between Serum IgE Level and Anxiety, Depression, Somatization and Quality of Life in Pediatric Asthma

Abstract

The main purpose of the current study is to explore the potential relationship of asthma with depression, somatic predisposition, quality of life, manifest anxiety and Serum levels of IgE level. 141 participants between 6 and 12 years old were recruited and the following scales were used: Child Depression Inventory, Revised Version of Child Manifest Anxiety Scale, Pediatric Asthma Quality of Life Questionnaire and the Somatic Complaints Subscale of Child Behavior Check List. Based on asthma control level, severity of asthma was assessed by the specialists and the serum levels of IgE were assessed by using ELISA technique. Initially, correlation analysis conducted between expressed levels of anxiety, depression, quality of life, somatic complaints, asthma and serum levels of IgE. The results indicated that there was a highly correlated relationship between serum levels of IgE and manifest anxiety levels among uncontrolled asthma group. These results suggested that, since the strong correlational relationship between the serum levels of IgE and manifest anxiety would have an effect on asthma control, future research should focus on this relationship from the aspect of psychoneuroimmunology.

Keywords

• asthma
• pediatric asthma
• ige
• mental health