Association of vitamin D deficiency and preterm birth

Abstract

In 70 % of cases of neonatal death, in 36 % of cases of infant mortality, in 25–50 % of cases of long-term neurological consequences in children, one of the causes is preterm birth. The course of pregnancy depends on the availability of vitamin D. The aim of the study was to determine the level of vitamin D and to analyze the obstetric and gynecological history in patients with preterm labor. Materials and methods. The study included 35 patients with preterm delivery and 30 women with the physiological course of labor. In the surveyed, vitamin D sufficiency was assessed by the content of 25(OH)D in blood serum, which was determined according to the clinical recommendations of the Russian Association of Endocrinologists, using the enzyme immunoassay method. Results. In patients with preterm labor, vitamin D deficiency and a high level of chronic inflammatory diseases of the respiratory, kidney and pelvic organs were revealed. Conclusions. Therefore, when managing pregnant women, it is necessary to take into account their availability of vitamin D and, possibly, recommend taking vitamin D preparations from the period of preconception preparation and during gestation.

Keywords

• preterm birth
• vitamin d deficiency
• risk factors
• premature newborns
• quality of life