Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Andrea J. Parsons; Sabrina I. Ophir; J. Andrew Duty; Thomas A. Kraus; Kathryn R. Stein; Thomas M. Moran; Domenico Tortorella

doi:10.1038/s42003-022-03294-z

Communications Biology (Apr 2022)

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Andrea J. Parsons,
Sabrina I. Ophir,
J. Andrew Duty,
Thomas A. Kraus,
Kathryn R. Stein,
Thomas M. Moran,
Domenico Tortorella

Affiliations

Andrea J. Parsons: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Sabrina I. Ophir: Department of Microbiology, Icahn School of Medicine at Mount Sinai
J. Andrew Duty: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Thomas A. Kraus: Center of Therapeutic Antibody Development, Icahn School of Medicine at Mount Sinai
Kathryn R. Stein: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Thomas M. Moran: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Domenico Tortorella: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s42003-022-03294-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal