OTA International (Apr 2021)

The induced membrane technique for bone defects: Basic science, clinical evidence, and technical tips

  • Graeme Hoit, MD,
  • Michael S. Kain, MD,
  • Jeremy W. Sparkman, DO,
  • Brent L. Norris, MD,
  • Janet D. Conway, MD,
  • J. Tracy Watson, MD,
  • Paul Tornetta, III, MD,
  • Aaron Nauth, MD, MSc

DOI
https://doi.org/10.1097/OI9.0000000000000106
Journal volume & issue
Vol. 4, no. 2S
p. e106

Abstract

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Abstract. The clinical management of large bone defects continues to be a difficult clinical problem to manage for treating surgeons. The induced membrane technique is a commonly employed strategy to manage these complex injuries and achieve bone union. Basic science and clinical evidence continue to expand to address questions related to the biology of the membrane and how interventions may impact clinical outcomes. In this review, we discuss the basic science and clinical evidence for the induced membrane technique as well as provide indications for the procedure and technical tips for performing the induced membrane technique.