PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Gommaar D’Hulst; Inés Soro-Arnaiz; Evi Masschelein; Koen Veys; Gillian Fitzgerald; Benoit Smeuninx; Sunghoon Kim; Louise Deldicque; Bert Blaauw; Peter Carmeliet; Leigh Breen; Peppi Koivunen; Shi-Min Zhao; Katrien De Bock

doi:10.1038/s41467-019-13889-6

Nature Communications (Jan 2020)

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Gommaar D’Hulst,
Inés Soro-Arnaiz,
Evi Masschelein,
Koen Veys,
Gillian Fitzgerald,
Benoit Smeuninx,
Sunghoon Kim,
Louise Deldicque,
Bert Blaauw,
Peter Carmeliet,
Leigh Breen,
Peppi Koivunen,
Shi-Min Zhao,
Katrien De Bock

Affiliations

Gommaar D’Hulst: Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich
Inés Soro-Arnaiz: Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich
Evi Masschelein: Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich
Koen Veys: Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB
Gillian Fitzgerald: Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich
Benoit Smeuninx: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston
Sunghoon Kim: Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Gwanak-gu
Louise Deldicque: Institute of Neuroscience, Université catholique de Louvain
Bert Blaauw: Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, University of Padova
Peter Carmeliet: Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB
Leigh Breen: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston
Peppi Koivunen: Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu
Shi-Min Zhao: Obstetrics and Gynaecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences
Katrien De Bock: Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich

DOI: https://doi.org/10.1038/s41467-019-13889-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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