Exercise‐induced improvement of glycemic fluctuation and its relationship with fat and muscle distribution in type 2 diabetes

Dan Liu; Ying Zhang; Qian Wu; Rui Han; Di Cheng; Liang Wu; Jingyi Guo; Xiangtian Yu; Wenli Ge; Jiacheng Ni; Yaohui Li; Tianshu Ma; Qichen Fang; Yufei Wang; Yan Zhao; Yanan Zhao; Biao Sun; Huating Li; Weiping Jia

doi:10.1111/1753-0407.13549

Journal of Diabetes (Apr 2024)

Exercise‐induced improvement of glycemic fluctuation and its relationship with fat and muscle distribution in type 2 diabetes

Dan Liu,
Ying Zhang,
Qian Wu,
Rui Han,
Di Cheng,
Liang Wu,
Jingyi Guo,
Xiangtian Yu,
Wenli Ge,
Jiacheng Ni,
Yaohui Li,
Tianshu Ma,
Qichen Fang,
Yufei Wang,
Yan Zhao,
Yanan Zhao,
Biao Sun,
Huating Li,
Weiping Jia

Affiliations

Dan Liu: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Ying Zhang: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Qian Wu: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Rui Han: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Di Cheng: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Liang Wu: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Jingyi Guo: Clinical Research Center Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Xiangtian Yu: Clinical Research Center Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Wenli Ge: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Jiacheng Ni: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Yaohui Li: School of Sports Science and Physical Education Nanjing Normal University Nanjing China
Tianshu Ma: Department of Kinesiology Nanjing Sport Institute Nanjing China
Qichen Fang: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Yufei Wang: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Yan Zhao: Department of Sports and Health Science Nanjing Sport Institute Nanjing China
Yanan Zhao: School of Sports Science and Physical Education Nanjing Normal University Nanjing China
Biao Sun: Department of Kinesiology Nanjing Sport Institute Nanjing China
Huating Li: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China
Weiping Jia: Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China

DOI: https://doi.org/10.1111/1753-0407.13549
Journal volume & issue: Vol. 16, no. 4
pp. n/a – n/a

Abstract

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Abstract Aims Management of blood glucose fluctuation is essential for diabetes. Exercise is a key therapeutic strategy for diabetes patients, although little is known about determinants of glycemic response to exercise training. We aimed to investigate the effect of combined aerobic and resistance exercise training on blood glucose fluctuation in type 2 diabetes patients and explore the predictors of exercise‐induced glycemic response. Materials and Methods Fifty sedentary diabetes patients were randomly assigned to control or exercise group. Participants in the control group maintained sedentary lifestyle for 2 weeks, and those in the exercise group specifically performed combined exercise training for 1 week. All participants received dietary guidance based on a recommended diet chart. Glycemic fluctuation was measured by flash continuous glucose monitoring. Baseline fat and muscle distribution were accurately quantified through magnetic resonance imaging (MRI). Results Combined exercise training decreased SD of sensor glucose (SDSG, exercise‐pre vs exercise‐post, mean 1.35 vs 1.10 mmol/L, p = .006) and coefficient of variation (CV, mean 20.25 vs 17.20%, p = .027). No significant change was observed in the control group. Stepwise multiple linear regression showed that baseline MRI‐quantified fat and muscle distribution, including visceral fat area (β = −0.761, p = .001) and mid‐thigh muscle area (β = 0.450, p = .027), were significantly independent predictors of SDSG change in the exercise group, as well as CV change. Conclusions Combined exercise training improved blood glucose fluctuation in diabetes patients. Baseline fat and muscle distribution were significant factors that influence glycemic response to exercise, providing new insights into personalized exercise intervention for diabetes.

Published in Journal of Diabetes

ISSN: 1753-0393 (Print); 1753-0407 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://onlinelibrary.wiley.com/journal/17530407

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