精准医学杂志 (Oct 2023)
ASSOCIATION OF PERIPHERAL BLOOD NEUTROPHIL-TO-LYMPHOCYTE RATIO AND LYMPHOCYTE-TO-MONOCYTE RATIO WITH CAROTID ATHEROSCLEROSIS IN PATIENTS IN TYPE 2 DIABETES MELLITUS
Abstract
Objective To investigate the association of plasma neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) with carotid atherosclerosis (CAS) in type 2 diabetes mellitus(T2DM). Methods A total of 211 T2DM patients who attended Department of Endocrinology and Department of Health Care in our hospital from August 2021 to October 2022 were enrolled as experimental group, and according to the presence or absence of CAS, the experimental group was further divided into CAS group with 136 patients and non-CAS group with 75 patients. A total of 47 individuals who underwent physical examination in Physical Examination Center of our hospital during the same period of time were enrolled as control group. The three groups were compared in terms of general information and laboratory examination results including routine blood test and blood biochemistry. The Pearson correlation analysis was used to investigate the correlation of NLR and LMR with the clinical indices of T2DM patients with CAS, and the multivariate logistic regression analysis was used to investigate the influence factors for CAS in T2DM patients. Results There were significant differences between the three groups in age, body mass index, course of disease, systolic pressure, plasma neutrophil count, lymphocyte count, monocyte count, NLR, LMR, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (χ2=33.651,14.038,F=4.714-68.693,H=6.192-112.809,P<0.05). The Pearson correlation analysis showed that in the experimental group, plasma NLR was positively correlated with FBG and HbA1c (r=0.232,0.273,P<0.05); plasma LMR was positively correlated with HDL-C (r=0.155,P<0.05) and was negatively correlated with course of di-sease, systolic pressure, TC, FBG, and HbA1c (r=-0.353--0.131,P<0.05). The multivariate logistic regression analysis showed that age, course of disease, LMR, NLR, and HbA1c were influence factors for CAS in T2DM patients (P<0.05), and the receiver operating characteristic (ROC) curve showed that the level of plasma NLR and LMR, with an area under the ROC curve of >0.70, had a relatively high value in evaluating the risk of CAS in T2DM patients Conclusion The level of plasma NLR and LMR are significantly associated with the development of CAS in T2DM patients and can predict the development of T2DM with CAS to a certain extent.
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