Antioxidant, Antimicrobial and Wound Healing Potential of Helicteres isora Linn. Leaf Extracts

Abstract

Objective: To investigate the antioxidant, antimicrobial and wound healing potential of Helicteres isora Linn. leaf extracts. Methods: The petroleum ether, chloroform, acetone, ethanol and hydroalcoholic extracts of leaves were screened for phytochemicals. The 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) radical scavenging tests and reducing power assays were performed to measure antioxidant activity; disc diffusion methods were used to evaluate antimicrobial potential. Wound healing activity was evaluated by incision and excision wound rat models. Results: The extracts contained mainly sterols and flavonoids. The hydroalcoholic extract showed remarkable antioxidant and antimicrobial potential and significant (P < 0.05) wound healing activity. Conclusions: The identified activities of the hydroalcoholic extract may be attributable to its constituent phytochemicals.

Keywords

• Helicteres isora Linn
• Phytochemical screening Antioxidant Antimicrobial
• Incision wound Excision wound
• Period of epithelization