Nature Communications (Nov 2019)
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
- Karina Chan,
- Francis Robert,
- Christian Oertlin,
- Dana Kapeller-Libermann,
- Daina Avizonis,
- Johana Gutierrez,
- Abram Handly-Santana,
- Mikhail Doubrovin,
- Julia Park,
- Christina Schoepfer,
- Brandon Da Silva,
- Melissa Yao,
- Faith Gorton,
- Junwei Shi,
- Craig J. Thomas,
- Lauren E. Brown,
- John A. Porco,
- Michael Pollak,
- Ola Larsson,
- Jerry Pelletier,
- Iok In Christine Chio
Affiliations
- Karina Chan
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- Francis Robert
- Department of Biochemistry, Oncology and Goodman Cancer Centre, McGill University
- Christian Oertlin
- Department of Oncology-Pathology, Karolinska Institute
- Dana Kapeller-Libermann
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- Daina Avizonis
- Department of Biochemistry, Oncology and Goodman Cancer Centre, McGill University
- Johana Gutierrez
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- Abram Handly-Santana
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- Mikhail Doubrovin
- Department of Radiology, Columbia University Medical Center
- Julia Park
- Cold Spring Harbor Laboratory
- Christina Schoepfer
- Cold Spring Harbor Laboratory
- Brandon Da Silva
- Cold Spring Harbor Laboratory
- Melissa Yao
- Cold Spring Harbor Laboratory
- Faith Gorton
- Cold Spring Harbor Laboratory
- Junwei Shi
- Department of Cancer Biology, University of Pennsylvania
- Craig J. Thomas
- National Cancer Institute
- Lauren E. Brown
- Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University
- John A. Porco
- Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University
- Michael Pollak
- Department of Medicine and Oncology, McGill University
- Ola Larsson
- Department of Oncology-Pathology, Karolinska Institute
- Jerry Pelletier
- Department of Biochemistry, Oncology and Goodman Cancer Centre, McGill University
- Iok In Christine Chio
- Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-13086-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and glutaminase can impact PDA proliferation.
