The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner

Bisrat T. Woldemichael; Ali Jawaid; Eloïse A. Kremer; Niharika Gaur; Jacek Krol; Antonin Marchais; Isabelle M. Mansuy

doi:10.1038/ncomms12594

Nature Communications (Aug 2016)

The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner

Bisrat T. Woldemichael,
Ali Jawaid,
Eloïse A. Kremer,
Niharika Gaur,
Jacek Krol,
Antonin Marchais,
Isabelle M. Mansuy

Affiliations

Bisrat T. Woldemichael: Laboratory of Neuroepigenetics, University of Zurich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich
Ali Jawaid: Laboratory of Neuroepigenetics, University of Zurich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich
Eloïse A. Kremer: Laboratory of Neuroepigenetics, University of Zurich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich
Niharika Gaur: Laboratory of Neuroepigenetics, University of Zurich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich
Jacek Krol: Friedrich Miescher Institute for Biomedical Research
Antonin Marchais: Institute of Agricultural Sciences, Swiss Federal Institute of Technology
Isabelle M. Mansuy: Laboratory of Neuroepigenetics, University of Zurich/Swiss Federal Institute of Technology, Brain Research Institute, Neuroscience Center Zürich

DOI: https://doi.org/10.1038/ncomms12594
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Protein phosphatase1 (PP1), a signalling and transcriptional regulator, and epigenetic modulator is known to be a memory suppressor. Here the authors show that memory control by PP1 involves the microRNA cluster miR-183/96/182, and that this cluster is selectively regulated during memory formation in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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